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      Pentosan Polysulfate

      PENTOSAN POLYSULFATE

      What is Pentosan Polysulfate?

      Pentosan polysulfate is a semi-synthetic polysulfated xylan used for the relief of Osteoarthritis. The mechanism of PPS action in osteoarthritis is multifactorial, with both stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation. In one study, after a series of four to six intra- articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity.

      How Does Pentosan Polysulfate work?

      The mechanism of PPS action in osteoarthritis is multifactorial, with both stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation. This is mainly used for osteoarthritis and inflammatory related skeletal conditions.

      Patient Benefits

      Pentosan Polysulfate has been shown to:

      • Reduces inflammation
      • Optimizing Peptides
      • Anti-thrombotic properties
      • Helps with osteoarthritis
      • Systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation
      • Stimulates cartilage matrix synthesis and prevention of cartilage.
      PENTOSAN POLYSULFATE

      Frequently Asked Questions

      What is Pentosan Polysulfate?

      Pentosan polysulfate is a semi-synthetic polysulfated xylan used most for the relief of Osteoarthritis

      What can pentosan polysulfate help with?

      The mechanism of PPS action in osteoarthritis is multifactorial, with both stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation. This is mainly used for osteoarthritis and inflammatory related skeletal conditions.

      What is the recommended dosing schedule?

      The recommended dose is 2mg/kg via subcutaneous injection twice weekly for 6 weeks.

      Are there any side effects?

      Common side effects include injection site redness, diarrhea, nausea, headache.

      Will this help me lose weight?

      Pentosan polysulfate will not help people to lose weight.

      Where is this product made/manufactured?

      All medications are compounded in house at Tailor Made Compounding in the United States. Tailor Made Compounding is a 503A compounding pharmacy outfitted with two USP 795 Non-Sterile compounding facilities, three USP 797 Sterile compounding facilities, and one USP 800 Hazardous Sterile compounding facility.

      Can this product be taken by pregnant women or women who are nursing?

      It is not recommended that this product be taken by those who are pregnant or nursing without consulting with a medical professional first.

      Can men and women take this medication?

      Pentosan Polysulfate poses no issues that would be sex dependent and has been shown to be successful in both men and women.

      Can I drink alcohol while taking Pentosan Polysulfate?

      Pentosan Polysulfate does not exhibit any chemical properties that would require any kind of food or dietary restrictions while taking.

      Does Pentosan Polysulfate require refrigeration?

      Injectable peptides should be stored in the refrigerator but are safe outside of refrigeration for up to 7 days.

      Is it safe to travel with this product?

      As a 503A pharmacy, we require patient specific prescriptions for all items. As a prescribed medication each product is safe to travel with and should not be seized. All products are stable for up to 7 days outside of refrigeration but should be limited if possible during travel. Stability data also indicates that this medication is not damaged or compromised when exposed to x-rays during standard security checks.


      ‡ These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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